Structural basis of Fic-mediated adenylylation
نویسندگان
چکیده
منابع مشابه
The fic domain: regulation of cell signaling by adenylylation.
We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core HPFxxGNGR motif and are conserved from bacteria to humans. We demonstrate that the Fic domains of IbpA catalyze a unique reversible adenylylation event that uses ATP to add an adenosine monophosphate (AMP) moiety to...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2010
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.1867